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JOB DESCRIPTION AND POSITION REQUIREMENTS:
Epigenetic regulation in normal and malignant hematopoiesis:
The Penn State College of Medicine, Department of Pediatric Hematology/Oncology, in Hershey, PA at is currently accepting applications for entry- and senior-level postdoctoral/Scientist positions. The lab focuses on delineating the epigenetic pathways that regulate normal hematopoiesis and to further determine how regulatory networks are perturbed in leukemia. Our current research focuses are: 1) Investigating the underlying molecular mechanisms by which 3D genome topology controls the hematopoietic transcription program and lineage differentiation in normal and malignant hematopoiesis. 2) Delineating the role of long noncoding RNAs in regulating CTCF boundary function during hematopoiesis and leukemogenesis. 3) Epigenetic and transcriptional regulation of hematopoietic stem cell function. We utilize a variety of approaches including biochemical, proteomic, genomic, genome editing, and mouse modeling to study these questions. Here are representative recent publications from the lab (Luo et al., Blood, 2018, 132 (8): 837-848; Luo et al., 2019, Cancer Cell, 36: 645-659; Zeisig et al., Science Translational Medicine, 2021, 13 (482): eabc4822; Zhu et al., Nature Communications, 2021, 12 (1): 1956. Doi: 10.1038/s41467-021-22095-2); Li et al., 2020. NAR, 48(6): 3119-3133.
Candidates should have obtained a PhD or an MD/PhD degree in the fields of molecular biology, biochemistry, bioinformatics, mouse genetics or a related field in hand. The candidate should have evidence of prior productive scientific work in the form of publications in peer-reviewed journals.
Prior experience in the study of gene regulation, hematopoiesis, and/or use of mouse models is preferred along with teaching experience. Interested candidates should upload their Curriculum Vitae and a cover letter describing their background and research interests and additionally send to firstname.lastname@example.org or email@example.com.
This is a limited-term appointment funded for one year from date of hire.
Employment will require successful completion of background check(s) in accordance with University polices.
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Employment with the University will require successful completion of background check(s) in accordance with University policies.
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